The major side effects of topotecan are:
- Low blood counts
- Susceptibility to infection
Topotecan hydrochloride (trade name Hycamtin) is a chemotherapy agent that is a topoisomerase I inhibitor.
It is often used in the treatment of ovarian and lung cancers, as well as other cancer types.
Topotecan intercalates between DNA. This intercalation disrupts the DNA duplication machinery when it finds a site in the DNA where topotecan is intercalated. This disruption prevents DNA replication, and ultimately leads to cell death.
Fluorourasil is a drug which is used in the treatment of cancer. It is a irreversible inhibitor of thymidylate synthase. It belongs to the family of drugs called antimetabolites and is typically administered with leucovorin.
Side effects of fluorourasil include:
- cardiac toxicity.