Cisplatin or cisplatinum (trade names Platinol) is a cytotoxic chemotherapy drug.
It is used to treat various types of cancers, including:
- small cell lung cancer
- ovarian cancer
- cervical cancer
- germ cell tumors.
Cisplatin was the first platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).
Side effects of Cisplatinum include:
- Nephrotoxicity (kidney damage)
- Neurotoxicity (nerve damage)
- Nausea and vomiting
- Ototoxicity (hearing loss)
- Electrolyte disturbance