Dame Deborah James, who died aged 40 of bowel cancer, spent the last 5 years of her life raising awareness about her type of cancer, but also fighting to make personalised medicine more widely available for cancer patients.
Personalized medicine is therapy customized for an individual and has become more readily available as the cost of gene sequencing has been significantly reduced. An example is when treatment is targeted to a specific type of cancer cells.
HealthPad had partnered with a consortium of leading cancer specialists to explain what personalised medicine means and what it can do for cancer patients.
The HealthPad Team would like to join the many people who have admired Dame Deborah for her courage and determination.
Thank you and farewell, BowelBabe.
#bowelbabe #damedeborahjames #personalisedmedicinego to cluster
The London Gastrointestinal Associates is a leading Private Gastroenterologist in London that perform a complete range of endoscopy including gastroscopy, capsule endoscopy, colonoscopy, ERCP and endoscopic ultrasound.
It consists a cohesive team of gastrointestinal physicians & surgeons, consultant gastroenterologist in London.
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Publications by Dr Matthew Banks
Should patients expect their colonoscopy to reach the standards experienced by bowel cancer screening patients?
Frontline Gastroenterol 2012;3:122-123
Mannath J, Banks MR
Emerging technologies in Endoscopic Imaging
F1000 Med Rep. 2012;4:3. Epub 2012 Feb 1.
Kent A & Banks MR
Functional Gastrointestinal Disorders: Diarrhea
Gastroenterology Clinics of North America. Hunt (eds),
The modern investigation and management of gastro-oesophageal reflux disease. Clinical Medicine
Burleigh DE & Banks MR
Stimulation of intestinal secretion by vasoactive intestinal peptide and cholera toxin. Autonomic Neuroscience.
Farthing MJG, Casburn-Jones A, Banks MR
Diarrhoea. Prescriber 2003;14 (20):48-59.
Farthing MJG, Casburn-Jones A, Banks MR.
Getting control of intestinal secretion: thoughts for 2003.
Digestive and Liver Disease 2003;35:378-385
Banks MR, Farthing MJG.
Fluid and electrolyte absorption. Current Opinion in Gastroenterology 2001;
18 (2): 176-181.
Banks MR, Farthing MJG.
Current management of Acute Diarrhoea. Prescriber 2001;
Banks MR, Farthing MJG.
The Management of Acute Diarrhoea. Prescriber 2000;
Pasha Y, Banks M.
Medical mystery: an unusual cause of anaemia
Br J Hosp Med (Lond). 2010 Feb;71(2):113.
Pasha Y, Pickard L, Cohen P, Banks MR
An unusual endoscopic diagnosis for acute epigastric pain
Scand J Gastro 2008;43(9):1151-2.
Pasha Y, White WJ, Chew NS, Banks M.
The importance of never ignoring an unexplained metabolic acidosis. Incarcerated femoral hernia. QJM.
2008 Oct;101(10):825-6. Epub 2008 Aug 28.
Green L, Banks MR
HIV associated encephalopathy, a grey case. Int J STD’s AIDS.
1995; 6: 744
Radiofrequency ablation for early oesophageal squamous neoplasia: Outcomes form United Kingdom registry.
Rehan J Haidry, Mohammed A Butt, Jason Dunn, Matthew Banks, Abhinav Gupta, Howard Smart, PradeepBhandari, Lesley Ann Smith, Robert Willert, Grant Fullarton, Morris John, Massimo Di Pietro, Ian Penman, Marco Novelli, Laurence B Lovat
World Journal of Gastroenterology 09/2013; 19(36):6011-6019. 2.47
Radiofrequency Ablation (Rfa) And Endoscopic Mucosal Resection For Dysplastic Barrett’s Esophagus And Early Esophageal Adenocarcinoma: Outcomes Of Uk National Halo Rfa Registry.
R J Haidry, J M Dunn, M A Butt, M Burnell, A Gupta, S Green, H Miah, H L Smart, P Bhandari, L Smith, R Willert, G Fullarton, M Di Pietro, C Gordon, I Penman, H Barr, P Patel, P Boger, N Kapoor, B Mahon, J Hoare, R Narayanasamy, D O’Toole, E Cheong, N C Direkze, Y Ang, M Novelli, M R Banks, L B Lovat
Gastroenterology. 2013 Mar 28.doi:pii: S0016-5085(13)00459-9. 10.1053/j.gastro.2013.03.045
Wallace MB, Crook JE, Saunders M, Lovat L, Coron E, Waxman I, Sharma P, Hwang JH, Banks M, DePreville M, Galmiche JP, Konda V, Diehl NN, Wolfsen HC. Multicenter, randomized, controlled trial of confocal laserendomicroscopy assessment of residual metaplasia after mucosal ablation or resection of GI neoplasia in Barrett’s esophagus. GastrointestEndosc. 2012 Sep;76(3):539-47.e1. doi: 10.1016/j.gie.2012.05.004. Epub 2012 Jun 28
Dunn JM, Mackenzie GD, Banks MR, Mosse CA, Haidry R, Green S, Thorpe S, Rodriguez-Justo M, Winstanley A, Novelli MR, Bown SG, Lovat LB. A randomised controlled trial of ALA vs. Photofrin photodynamic therapy for high-grade dysplasia arising in Barrett’s oesophagus. Lasers Med Sci. 2012 Jun 15.
Banks MR, Haidry R, Butt MA, Whitley L, Stein J, Langmead L, Bloom SL, O’Bichere A, McCartney S, Basherdas K, Rodriguez-Justo M, Lovat LB. High resolution colonoscopy in a bowel cancer screening program improves polyp detection. World J Gastroenterol. 2011 Oct 14;17(38):4308-13.
Dunn JM, Banks MB, Oukris D, McKenzie GD, Thorpe S, Winstanly A, Novelli MR, Bown S, Lovat LB. Radiofrequency ablation is an effective treatment for high grade dysplasia in Barrett’s esophagus after failed Photodynamic therapy – a case series. Endoscopy. 2011 Jul;43(7):627-30
Dunn JM, Mackenzie GD, Oukrif D, Mosse CA, Banks MR, Thorpe S, Sasieni P, Bown SG, Novelli MR, Rabinovitch PS, Lovat LB. Image cytometry accurately detects DNA ploidy abnormalities and predicts late relapse to high-grade dysplasia and adenocarcinoma in Barrett’s oesophagus following photodynamic therapy. Br J Cancer 2010 May 25;102(11):1608-17
Kent AJ, Graf B, Prasad P, Banks M, Feher M. Diabetes Treatments, Gastrointestinal Symptoms and lower Gastrointestinal Endoscopy. Br J Diabetes &Vasc Dis 2009; 9: 129
Banks MR, Farthing MJG, Robberecht P, Burleigh DE. Anti-secretory actions of a novel vasoactive intestinal polypeptide (VIP) antagonist. British J Pharmacol 2005; 144: 994-1001.
Banks MR, Golder M, Farthing MJG, Burleigh DE. Intracellular potentiation between two second messenger systems may contribute to cholera toxin-induced intestinal secretion in humans.GUT 2004;53:50-57
Mulcahy HE, Kelly P, Banks MR, Connor P, Patchet SE, Farthing MJG, Fairclough PD, Kumar PJ. Factors Associated with Tolerance to, and Discomfort with, Unsedated Diagnostic Gastroscopy.Scand J Gast 2001; 36: 1352-1357
Banks MR, Kumar PJ, Mulcahy HE. Pulse Oximetry saturation levels during routine unsedated diagnostic upper gastrointestinal endoscopy.Scand J Gast 2001; 36: 105-109.
Pollock RCG, Banks MR, Fairclough PD, Farthing MJG. Dilutionaldiarrhoea – underdiagnosed and over-investigated.Europ J GastHep. 2000; 12: 1-3
Rockall AG, Lamb GM, Banks MR, Barrett SP, Al-Kutoubi MA. A prospective study of bacteraemia and bacterial contamination rates of catheters and wires during angiography.JInterventRadiol 1997; 12; 107-111.
Dr Matthew Banks is a consultant gastroenterologist at University College London Hospitals (UCLH) where he has been director of endoscopy for 6 years, leading the largest Barrett’s oesophagus centre in the UK. He works privately in Harley Street, The Lister Hospital Chelsea, The London Clinic and Princess Grace Hospitals where he founded a team of gastroenterologist and surgeons- London Gastrointestinal Associates. He was also Director of Endoscopy at Chelsea & Westminster Hospital.
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WHAT ARE THE THREE MOST IMPORTANT BREAKTHROUGHS IN CANCER THERAPY?
The three most important breakthroughs in cancer therapy are difficult to state because there have been so many advances over time. However, if I were to choose three, they would be for different reasons.
The first that I would choose is the transformation of the prognosis of breast cancer, which has been achieved not only through research, but through the political will of governments and lobby organizations to provide funding for research, almost in a space-program type way. This has demonstrated how you can really fix a problem if you throw enough money at it. We have seen dramatic improvements in breast cancer survival artes, despite rising incidence rates of the disease.
The second example I would choose is bowel cancer. Bowel cancer used to be an extremely poor prognosis and have a very poor outlook. For no other disease have we seen such incorporation of biological therapies into a disease, which has truly transformed bowel cancer’s outcome. In particular, it is an example of a very difficult thing called metastasis, which has been successfully dealt with and cured.
Metastasis means more than one cancerous tumour and describes when a tumour spreads to non adjacent tissue.
The third example I would choose is a rare and very bad outlook disease called GIST: gastrointestinal stromal tumors. These tumors use to have a very bad prognosis. The reason I choose GIST as a major advance is because of the fact that we have completely understood the biology of GISTs and this has transformed their prognosis. Using a single biotherapy drug called Gleevec has shown the way to the future and what research can achieve.
Gleevec represents a new class of cancer drugs and a new way of thinking about cancer. These molecularly targeted drugs are different because they target abnormal proteins that are fundamental to the cancer itself.
Each year, approximately 3,300 to 6,000 adults in the United States will be diagnosed with a GIST. GISTs belong to a group of cancers called soft tissue sarcoma. Soft tissue sarcomas are a group of cancers that develop in the tissues that support and connect the body, and the sarcoma cells resemble the cells that hold the body together, including fat cells, muscles, nerves, tendons, joints, blood vessels, or lymph vessels. The most common locations in the body are in the stomach. GIST is a type of tumor that occurs in the gastrointestinal or digestive tract, including the esophagus, stomach, gallbladder, liver, small intestine, colon, rectum, and lining of the gut. GISTs are different from other types of gastrointestinal tumors because of the type of tissue in which they start